Hacker Newsnew | past | comments | ask | show | jobs | submitlogin

> How did you get involved with harm-reduction work?

> ... Now, I’m a daily intravenous meth user.

I really didn't expect the harm reduction worker to be actively addicted.



That’s the point of harm reduction. If we stop focusing on treating those with drug addictions as criminals, they can potentially contribute to our society instead of having their lives destroyed by criminal convictions and medical issues from unsafe drug usage. Instead of being further cast out of society they can live with some level of dignity even if they cannot overcome their addiction.


I found it surprising too, on the basis of, it could pose perceived or actual conflicts of interest in their work. And of course the performance and/or liability risk on the org.

But you skipped the part of the quote where he's been abusing drugs since age 11 - it'd certainly be more alarming if he was sober but after working at the clinic for a bit, started taking up IV meth. But yes, still surprising, however there are benefits to serving the people that you can relate most to.


You’re implying a reversal of the Norse of events. He was a daily meth user before he was in harm Reduction.


> was a daily meth user before he was in harm Reduction

These stories usually feature someone who went clean. That it's someone who still using and contributing to society makes it unexpected. (I hadn’t considered the possibility of a functional meth addict.)


Plenty of functional Ritalin users. Very similar effect profiles (assuming the meth is clean), since they metabolize to the same thing.


Plenty of functional Adderall users also, which is mixed amphetamine salts.

And although more rare, functional desoxyn users too, which is a methamphetamine pill typically used for narcolepsy and severe obesity.


How many functional Ritalin/Adderall/Desoxyn users are injecting?


Probably as many as functional Tylenol users are injecting. In my meth days I knew of 2 people that injected. It was always smoked or, less commonly, taken orally.


Pure Meth isn't that much different than Adderall, and ~7% of the population is using Adderall...

Adderall users are doing all kind of productive things in society.

Why can't Meth users?


Adderall generally comes in a fixed quantity of lower potency than meth, and in beads designed to spread the release out over time. It's supposedly not easy to smoke it either.

Then there's just the nature of addiction. Some people seem predisposed to it. The Vietnam war is a good example. High percentage of heroin use there by US soldiers, but a much smaller percentage of the in-country users returned home with a habit. Another example is the high occurrence of addiction following bariatric surgery, with people who didn't have the issue prior.


7% seems high. Googling shows ~40 million prescriptions dispensed in 2021. Since CSA disallows refills and 90-day fills are extremely rare, that’s about 40/12=3 million patients, or roughly 1–2%.


I would be curious if other knowledgeable folks agree that pure meth isn’t that much different from Adderall on dimensions that are likely to be relevant.


“Methamphetamine (meth) is a stimulant. The FDA- approved brand-name medication is Desoxyn®.” https://www.dea.gov/sites/default/files/2020-06/Methamphetam... (pdf)

Adderall is regular (non-methylated) amphetamine, specifically a mixture of levo-amphetamine and dextro-amphetamine. There are minor differences in effect profile between methamphetamine and amphetamine, the biggest of these minor differences being in neuroprotectivity (it’s been a while since I’ve done the research but iirc amphetamine is mildly neuroprotective while meth is neutral or mildly negative, due to meth interrupting some metabolizing process). The major difference is that milligram-for-milligram, meth is 2-5x more potent than regular amphetamine.

The perception that they are very different is valid, though, because amphetamine is usually consumed therapeutically (lower doses, guaranteed purity, controlled dosing schedule, safer administration route) while meth is usually consumed recreationally (higher doses, unknown and often dubious purity, erratic dosing schedule, riskier administration routes). Injecting a quarter of a gram of street meth over a three day binge is much more harmful than taking 40mg Adderall extended release formulation by mouth every morning.


Adderall will have me overly focusing on one thing if I take a bit too much. Meth will have me sitting at the computer for 8 hours knowing I have other obligations if I take a bit too much. I'm also much more distracted and likely to hop to new random things on meth, versus hyper focusing on one thing.


tldr; pretty different in practice, trust your doctor, all that good stuff.

On some level, it is similar as they are both stimulants and nearly the same chemical. But my own research suggests the methyl group has a significant effect on how the body metabolizes the drug.

The methyl group makes it fat-soluble which allows it to cross the blood brain barrier. Apparently this causes it to have an effect on dopamine and serotonin receptors which it would otherwise not - hence the euphoric effect. It also cleaves into amphetamine in the blood stream which gives it a significantly higher half-life.

How you administer a drug is important, which is self explanatory. Most newer ADHD stimulants are made in such that they must be metabolized through the stomach.

Additionally, the dosage is important. Meth is not only more potent, but when abused is likely to be taken in 10x (or more) amount than a therapeutic dose.

So.. safe to say they are chemically similar but different in practice. This info is from my quick googling. I’m on a therapeutic dose of Adderall, and given its effect on my blood pressure I would be concerned taking meth due to all of the above. And this is why I have a doctor to help me with all of this.


There's another ADHD medicine called Desoxyn which is methamphetamine. Adderal is a mix of amphetamine salts, but it's still fair to say they're not very different. The main difference is in the common dosage.


Gasoline is not that much different from kerosine. Planes fly, why can't cars?


It's like an obese personal trainer.


> like an obese personal trainer

Eh, it's more like an obese doctor treating obese patients. The goal isn't become thin, but to reduce harm. Yes, the doctor should tell the patient they should lose weight. But in cases where that's unrealistic, there are second-best options before abandonment.




Guidelines | FAQ | Lists | API | Security | Legal | Apply to YC | Contact

Search: