Does it really matter if it hasn't gone through any testing? Have we forgotten about the Covid shot not going through any trials? We have people dropping dead left and right due Narcan not reversing the effects. The FDA NEEDS to come up with something that acts both like Narcan and Atipamezole, so we can start saving lives!

Also probably not approved because of a lack of randomized, double blind studies. But it would be really hard to run a study for a treatment like this. I can’t even imagine trying to get informed consent to try and enroll someone on the trial. So, without that, the best you could do would be to find a drug that is approved for something else that can be used off label.

I don’t think there are any easy answers here.

> So, without that, the best you could do would be to find a drug that is approved for something else that can be used off label.

Xylazine has a very rapid onset and a short half-life. So, as it can take >40 minutes for orally-administered drugs to be absorbed, there are really only two options that _might_ be legal and effective.

1) Administer an FDA-approved alpha-2 antagonist intravenously. There are no good options here. AFAIK, the only FDA-approved alpha-2 antagonist that's available as an intravenous injection is Thorazine -- and it does a hell of a lot besides counteract alpha-2 adrenoceptor activation. It's also an alpha-1 antagonist, dopamine antagonist, serotonin antagonist, and more. This likely makes it a little bit unpredictable in drug overdose scenarios.

2) Sidestep FDA approval with a fast-acting yohimbine nasal spray, administered as a "dietary supplement."

The FDA process is a terrible roadblock in situations like this. Intravenous atipamezole, which would be much better than either of the two options above, is available for veterinary use, but would be totally illegal for use in humans. (Like xylazine itself!)